Reactome | NNMT transfers CH3 from SAM to NAM to form MNA

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NNMT transfers CH3 from SAM to NAM to form MNA Show undefined attributes

catalystActivity	[CatalystActivity:10287906] nicotinamide N-methyltransferase activity of NNMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10287908
displayName	NNMT transfers CH3 from SAM to NAM to form MNA
eventOf	[Pathway:R-CFA-196807] Nicotinate metabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5359451] NNMT transfers CH3 from SAM to NAM to form MNA - Homo sapiens
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-197277] NAM [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NNMT transfers CH3 from SAM to NAM to form MNA nicotinamide + S-adenosyl-L-methionine => 1-methylnicotinamide + S-adenosyl-L-homocysteine
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-549282] MNA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5359451
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-196807] Nicotinate metabolism
(inferredTo)	[Reaction:R-HSA-5359451] NNMT transfers CH3 from SAM to NAM to form MNA

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