Reactome | GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol

Schema > Reaction > Entries

GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:5339530] Jassal, Bijay, 2014-03-04
catalystActivity	[CatalystActivity:5358708] D-glucose transmembrane transporter activity of GLUT1 / SLC2A1 tetramer [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643945] D-glucose transmembrane transporter activity of GLUT1 / SLC2A1 tetramer [plasma membrane] Structural analysis of the GLUT1 facilitative glucose transporter (review).
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5339530] Jassal, Bijay, 2014-03-04
crossReference	[DatabaseIdentifier:12667692] RHEA:60376
dbId	5339524
diseaseReaction	[FailedReaction:R-HSA-5632804] SLC2A1 tetramer does not transport Glc from extracellular region to cytosol - Homo sapiens
displayName	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol
edited	[InstanceEdit:5339530] Jassal, Bijay, 2014-03-04
eventOf	[Pathway:R-HSA-189200] Cellular hexose transport - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:6808140] D-glucose transmembrane transport
input	[SimpleEntity:R-ALL-70115] Glc [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:70141] Structural analysis of the GLUT1 facilitative glucose transporter (review). [LiteratureReference:8981572] FGF-21 as a novel metabolic regulator [LiteratureReference:70159] The predicted ATP-binding domains in the hexose transporter GLUT1 critically affect transporter activity
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol
negativePrecedingEvent	[NegativePrecedingEvent:9963453] Futile Cycle: GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region [NegativePrecedingEvent:9963434] Futile Cycle: SLC50A1 transports Glc from cytosol to extracellular region
orthologousEvent	[Reaction:R-PFA-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Plasmodium falciparum [Reaction:R-SCE-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Saccharomyces cerevisiae [Reaction:R-DDI-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Dictyostelium discoideum [Reaction:R-CEL-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-DME-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-GGA-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Gallus gallus [Reaction:R-XTR-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-DRE-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Danio rerio [Reaction:R-SSC-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Sus scrofa [Reaction:R-BTA-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Bos taurus [Reaction:R-CFA-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Canis familiaris [Reaction:R-RNO-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Rattus norvegicus [Reaction:R-MMU-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-70113] Glc [cytosol]
precedingEvent	[Reaction:R-HSA-450092] GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5340413] Positive regulation by 'FGF21 [extracellular region]' [NegativeRegulation:R-HSA-5358720] Negative regulation by 'ATP [cytosol]'
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5674208] D'Eustachio, Peter, 2015-02-11
revised	[InstanceEdit:450087] D'Eustachio, P, 2009-12-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5339524
summation	[Summation:5339532] Tetrameric GLUT1, the SLC2A1 gene product, associated with t...
updateTrackers	[UpdateTracker:9781299] Update Tracker - [Reaction:5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - v61:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781299] Update Tracker - [Reaction:5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - v61:[add_removeLiteratureReference, modifyText]
(normalReaction)	[FailedReaction:R-HSA-5632804] SLC2A1 tetramer does not transport Glc from extracellular region to cytosol
(hasEvent)	[Pathway:R-HSA-189200] Cellular hexose transport
(precedingEvent)	[NegativePrecedingEvent:9963458] Futile Cycle: GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol [NegativePrecedingEvent:9963442] Futile Cycle: GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol

Cite Us!