Reactome | GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol

GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol

Stable Identifier

R-HSA-5339524

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol

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Tetrameric GLUT1, the SLC2A1 gene product, associated with the plasma membrane, mediates the facilitated diffusion of glucose (Glc) into cells. GLUT1 is expressed by many cell types, notably endothelial cells, red blood cells and cells of the brain. Its low Km for glucose (~1 mM) relative to normal blood glucose concentration (~5 mM) allows these cells to take up glucose independent of changes in blood glucose levels. It has been purified from red blood cells and biochemically characterized (Hruz & Mueckler 2001, Liu et al. 2001). Cytosolic ATP associates with GLUT1 and inhibits its glucose transporter activity. Fibroblast growth factor 21 (FGF21) is a potent positive regulator of glucose uptake in differentiated mouse 3T3-L1 adipocytes and in primary human adipocytes, probably acting by stimulating SLC2A1 / GLUT1 gene transcription.

Literature References

PubMed ID	Title	Journal	Year
11425315	The predicted ATP-binding domains in the hexose transporter GLUT1 critically affect transporter activity. Golde, DW, Liu, Q, Vera, JC, Peng, H	Biochemistry	2001
15902306	FGF-21 as a novel metabolic regulator Hammond, LJ, Owens, RA, Moyers, JS, Micanovic, R, Koester, A, Gromada, J, Sandusky, GE, Jaskunas, SR, Galbreath, EJ, Kharitonenkov, A, Wroblewski, VJ, Shiyanova, TL, Brozinick, JT, Shanafelt, AB, Mehrbod, F, Ford, AM, Li, DS, Hawkins, ED	J. Clin. Invest.	2005
11681785	Structural analysis of the GLUT1 facilitative glucose transporter (review). Hruz, PW, Mueckler, MM	Mol Membr Biol	2001