Reactome | TFC7L2 mutants don't bind CTBP

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TFC7L2 mutants don't bind CTBP Show undefined attributes

authored	[InstanceEdit:5358797] Rothfels, Karen, 2014-04-03
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5334051] Rothfels, K, 2014-02-21
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575
dbId	5334052
disease	[Disease:4791250] colorectal cancer
displayName	TFC7L2 mutants don't bind CTBP
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
entityFunctionalStatus	[EntityFunctionalStatus:5339707] loss_of_function of TCF7L2 mutants [nucleoplasm]
eventOf	[Pathway:R-HSA-5339700] Signaling by TCF7L2 mutants - Homo sapiens
input	[CandidateSet:R-HSA-5333992] CTBPs [nucleoplasm] [CandidateSet:R-HSA-5339697] TCF7L2 mutants [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5334038] TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription [LiteratureReference:5334041] The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines [LiteratureReference:5334053] Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability [LiteratureReference:5334007] Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability [LiteratureReference:5334036] A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TFC7L2 mutants don't bind CTBP
normalReaction	[Reaction:R-HSA-5334050] TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5334052
summation	[Summation:5334043] TCF7L2 is subject to frameshift and missense mutations in ga...

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[Pathway:R-HSA-5339700] Signaling by TCF7L2 mutants