TFC7L2 mutants don't bind CTBP

Stable Identifier
Reaction [transition]
Homo sapiens
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TCF7L2 is subject to frameshift and missense mutations in gastric and colorectal cancers that abolish the CTBP binding domain (Duval et al, 1999a; Duval et al, 1999b; Duval et al, 2000; Tang et al, 2008). These mutant proteins fail to colocalize with CTBP and are unable to repress TCF-mediated transcription in vitro (Cuilliere-Dartigues et al, 2006).
Literature References
PubMed ID Title Journal Year
10919662 The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines

Rolland, S, Duval, A, Thomas, G, Tubacher, E, Hamelin, R, Bui, H

Cancer Res. 2000
16547505 TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription

Duval, A, El-Bchiri, J, Cuilliere-Dartigues, P, Hamelin, R, Fontanges, P, Buhard, O, Fléjou, JF, Krimi, A

Oncogene 2006
10485457 Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability

Duval, A, Thomas, G, Zhou, XP, Gayet, J, Hamelin, R, Iacopetta, B

Cancer Res. 1999
18621708 A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

Dodge, M, Lum, L, Gundapaneni, D, Michnoff, C, Tang, W, Roth, M

Proc. Natl. Acad. Sci. U.S.A. 2008
10597289 Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability

Duval, A, Ranzani, GN, Thomas, G, Lothe, RA, Hamelin, R, Iacopetta, B

Oncogene 1999
Normal reaction
Functional status

Loss of function of TCF7L2 mutants [nucleoplasm]

Name Identifier Synonyms
colorectal cancer DOID:9256
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