Reactome | TCF7L2 K485fs*25 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5334042] Rothfels, K, 2014-02-21
crossReference	[DatabaseIdentifier:12020782] Mondo:0001056
dbId	5334040
disease	[Disease:4791250] colorectal cancer [Disease:1500687] stomach cancer
displayName	TCF7L2 K485fs*25 [nucleoplasm]
endCoordinate	506
hasModifiedResidue	[FragmentReplacedModification:5334029] Replacement of residues 485 to 506 by SAFATYKVKAAASAHPLQMEAY
inDisease	true
literatureReference	[LiteratureReference:5334038] TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription [LiteratureReference:5334041] The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines
maxDepth	1
memberOf	[CandidateSet:R-HSA-5339697] TCF7L2 mutants [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:9827828] Orlic-Milacic, Marija, 2023-02-06
name	TCF7L2 K485fs*25
referenceEntity	[ReferenceGeneProduct:uniprot:Q9NQB0] UniProt:Q9NQB0 TCF7L2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-5334040
startCoordinate	1
updateTrackers	[UpdateTracker:9904553] Update Tracker - [EntityWithAccessionedSequence:5334040] TCF7L2 K485fs*25 [nucleoplasm] - v84:[modifyName]

(updatedInstance)	[UpdateTracker:9904553] Update Tracker - [EntityWithAccessionedSequence:5334040] TCF7L2 K485fs*25 [nucleoplasm] - v84:[modifyName]
(hasMember)	[CandidateSet:R-HSA-5339697] TCF7L2 mutants [nucleoplasm]

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