Reactome | MeSeOH is reduced to MeSeH by TXNRD1

Schema > Reaction > Entries

MeSeOH is reduced to MeSeH by TXNRD1 Show undefined attributes

authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
catalystActivity	[CatalystActivity:5359073] methylselenol reductase activity of TNXRD1:FAD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5263615] Williams, MG, 2014-02-12
dbId	5263614
displayName	MeSeOH is reduced to MeSeH by TXNRD1
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
eventOf	[Pathway:R-HSA-5263617] Metabolism of ingested MeSeO2H into MeSeH - Homo sapiens
followingEvent	[Reaction:R-HSA-2408541] MeSeH is methylated to Me2Se by MeSeH methyltransferase - Homo sapiens [Reaction:R-HSA-2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-5357663] MeSeOH [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5359370] Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	MeSeOH is reduced to MeSeH by TXNRD1
orthologousEvent	[Reaction:R-RNO-5263614] MeSeOH is reduced to MeSeH by TXNRD1 - Rattus norvegicus [Reaction:R-PFA-5263614] MeSeOH is reduced to MeSeH by TXNRD1 - Plasmodium falciparum [Reaction:R-CEL-5263614] MeSeOH is reduced to MeSeH by TXNRD1 - Caenorhabditis elegans [Reaction:R-DME-5263614] MeSeOH is reduced to MeSeH by TXNRD1 - Drosophila melanogaster [Reaction:R-GGA-5263614] MeSeOH is reduced to MeSeH by TXNRD1 - Gallus gallus [Reaction:R-BTA-5263614] MeSeOH is reduced to MeSeH by TXNRD1 - Bos taurus [Reaction:R-MMU-5263614] MeSeOH is reduced to MeSeH by TXNRD1 - Mus musculus
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-5357669] MeSeH [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-5263616] MeSeO2H is reduced to MeSeOH by TXNRD1 - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5263614
summation	[Summation:5422882] Thioredoxin reductase 1 (TXNRD1) homodimer is involved in th...

Referrals

(precedingEvent)	[Reaction:R-HSA-2408541] MeSeH is methylated to Me2Se by MeSeH methyltransferase [Reaction:R-HSA-2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase
(hasEvent)	[Pathway:R-HSA-5263617] Metabolism of ingested MeSeO2H into MeSeH