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MeSeOH is reduced to MeSeH by TXNRD1
Stable Identifier
R-HSA-5263614
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested MeSeO2H into MeSeH (Homo sapiens)
MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Thioredoxin reductase 1 (TXNRD1) homodimer is involved in the reduction of methylselenenic acid (MeSeOH) into methylselenol (MeSeH) (Gromer and Gross 2002).
Literature References
PubMed ID
Title
Journal
Year
11782468
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium
Gross, JH
,
Gromer, S
J. Biol. Chem.
2002
Participants
Input
H+ [cytosol]
MeSeOH [cytosol]
NADPH [cytosol]
Output
H2O [cytosol]
MeSeH [cytosol]
NADP+ [cytosol]
Participates
as an event of
Metabolism of ingested MeSeO2H into MeSeH (Homo sapiens)
Catalyst Activity
methylselenol reductase activity of TNXRD1:FAD dimer [cytosol]
Physical Entity
TNXRD1:FAD dimer [cytosol]
(Homo sapiens)
Activity
methylselenol reductase activity (GO:0098625)
Orthologous Events
MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)
MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)
MeSeOH is reduced to MeSeH by TXNRD1 (Gallus gallus)
MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)
MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)
MeSeOH is reduced to MeSeH by TXNRD1 (Rattus norvegicus)
Authored
Williams, MG (2014-05-06)
Reviewed
Rush, MG (2015-08-30)
Created
Williams, MG (2014-02-12)
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