Reactome | Toxicity of botulinum toxin type D (botD)

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Toxicity of botulinum toxin type D (botD) Show undefined attributes

authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
created	[InstanceEdit:5250954] D'Eustachio, Peter, 2014-01-31
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5250955
disease	[Disease:3632909] botulism
displayName	Toxicity of botulinum toxin type D (botD)
edited	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
eventOf	[Pathway:R-HSA-168799] Neurotoxicity of clostridium toxins - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5250607] botD HC:LC binds SV2A or B or C and GD2 on the target cell surface - Homo sapiens [BlackBoxEvent:R-HSA-5250600] botD:SV2:GD2 internalized from target cell plasma membrane to synaptic vesicle membrane - Homo sapiens [BlackBoxEvent:R-HSA-5250616] botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol - Homo sapiens [Reaction:R-HSA-194809] botD LC cleaves target cell VAMP1 - Homo sapiens [Reaction:R-HSA-5250606] botD LC cleaves target cell VAMP2 - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2020-12-07
literatureReference	[LiteratureReference:5250596] Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons [LiteratureReference:5251396] Botulism: the present status of the disease [LiteratureReference:5228359] Botulinum neurotoxin: a marvel of protein design [LiteratureReference:5250594] Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors [LiteratureReference:5250613] Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E [LiteratureReference:181778] Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Toxicity of botulinum toxin type D (botD)
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5250955
summation	[Summation:5251714] Botulinum toxin type D (botD) is only very rarely associated...
updateTrackers	[UpdateTracker:9776482] Update Tracker - [Pathway:5250955] Toxicity of botulinum toxin type D (botD) - v75:[modifyText, updateContainedRLE] [UpdateTracker:9786301] Update Tracker - [Pathway:5250955] Toxicity of botulinum toxin type D (botD) - v50:[modifyText, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9776482] Update Tracker - [Pathway:5250955] Toxicity of botulinum toxin type D (botD) - v75:[modifyText, updateContainedRLE] [UpdateTracker:9786301] Update Tracker - [Pathway:5250955] Toxicity of botulinum toxin type D (botD) - v50:[modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-168799] Neurotoxicity of clostridium toxins