Reactome | botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol

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botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol Show undefined attributes

authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
catalystActivity	[CatalystActivity:5250602] protein transmembrane transporter activity of botD:SV2:GD2 [synaptic vesicle membrane]
category	omitted
compartment	[Compartment:201753] synaptic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:5250610] D'Eustachio, Peter, 2014-01-28
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5250616
deleted	[Deleted:5250996] Deletion of instance: 181365 [Deleted:5251016] Deletion of instance: 168788 [Deleted:5250999] Deletion of instance: 181363 [Deleted:5251014] Deletion of instance: 181361
disease	[Disease:3632909] botulism
displayName	botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol
eventOf	[Pathway:R-HSA-5250955] Toxicity of botulinum toxin type D (botD) - Homo sapiens
followingEvent	[Reaction:R-HSA-5250606] botD LC cleaves target cell VAMP2 - Homo sapiens [Reaction:R-HSA-194809] botD LC cleaves target cell VAMP1 - Homo sapiens
input	[Complex:R-HSA-5250603] botD:SV2:GD2 [synaptic vesicle membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:201296] Translocation of botulinum neurotoxin light chain protease through the heavy chain channel [LiteratureReference:5228359] Botulinum neurotoxin: a marvel of protein design
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol
output	[EntityWithAccessionedSequence:R-CBO-181482] botD HC [synaptic vesicle membrane] [Complex:R-CBO-190038] botD LC:Zn2+ [cytosol] [SimpleEntity:R-ALL-5250593] GD2 [synaptic vesicle membrane] [DefinedSet:R-HSA-5324682] SV2A,B,C [synaptic vesicle membrane]
precedingEvent	[BlackBoxEvent:R-HSA-5250600] botD:SV2:GD2 internalized from target cell plasma membrane to synaptic vesicle membrane - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5250618] Positive regulation by 'H+ [synaptic vesicle lumen]'
regulationReference	[RegulationReference:9642361] Positive regulation by 'H+ [synaptic vesicle lumen]' Botulinum neurotoxin: a marvel of protein design
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5250616
summation	[Summation:5262820] By analogy to the process described for botulinum toxin type...
updateTrackers	[UpdateTracker:9786277] Update Tracker - [BlackBoxEvent:5250616] botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol - v50:[modifyText] [UpdateTracker:9776535] Update Tracker - [BlackBoxEvent:5250616] botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol - v75:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786277] Update Tracker - [BlackBoxEvent:5250616] botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol - v50:[modifyText] [UpdateTracker:9776535] Update Tracker - [BlackBoxEvent:5250616] botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol - v75:[modifyText]
(replacementInstances)	[Deleted:5250996] Deletion of instance: 181365 [Deleted:5251016] Deletion of instance: 168788 [Deleted:5250999] Deletion of instance: 181363 [Deleted:5251014] Deletion of instance: 181361
(precedingEvent)	[Reaction:R-HSA-5250606] botD LC cleaves target cell VAMP2 [Reaction:R-HSA-194809] botD LC cleaves target cell VAMP1
(hasEvent)	[Pathway:R-HSA-5250955] Toxicity of botulinum toxin type D (botD)