Reactome | B-WICH complex positively regulates rRNA expression

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B-WICH complex positively regulates rRNA expression Show undefined attributes

authored	[InstanceEdit:5250658] May, B, 2014-01-29
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5250945] May, B, 2014-01-31
dbId	5250924
displayName	B-WICH complex positively regulates rRNA expression
doi	10.3180/r-hsa-5250924.1
edited	[InstanceEdit:5250658] May, B, 2014-01-29
eventOf	[Pathway:R-HSA-5250913] Positive epigenetic regulation of rRNA expression - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24868] transcription initiation-coupled chromatin remodeling
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5250947] B-WICH complex binds rDNA promoter - Homo sapiens [Reaction:R-HSA-5250930] B-WICH recruits histone acetyltransferases - Homo sapiens [Reaction:R-HSA-5250938] B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:5250623] The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription [LiteratureReference:5250641] Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression [LiteratureReference:5250940] The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription [LiteratureReference:5250922] The chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes [LiteratureReference:5250647] The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation [LiteratureReference:6808623] Chromatin remodelling and transcription: be-WICHed by nuclear myosin 1
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	B-WICH complex positively regulates rRNA expression
orthologousEvent	[Pathway:R-GGA-5250924] B-WICH complex positively regulates rRNA expression - Gallus gallus [Pathway:R-DRE-5250924] B-WICH complex positively regulates rRNA expression - Danio rerio [Pathway:R-SSC-5250924] B-WICH complex positively regulates rRNA expression - Sus scrofa [Pathway:R-BTA-5250924] B-WICH complex positively regulates rRNA expression - Bos taurus [Pathway:R-CFA-5250924] B-WICH complex positively regulates rRNA expression - Canis familiaris [Pathway:R-RNO-5250924] B-WICH complex positively regulates rRNA expression - Rattus norvegicus [Pathway:R-MMU-5250924] B-WICH complex positively regulates rRNA expression - Mus musculus
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6808621] Percipalle, Pergiorgio, 2015-11-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5250924
summation	[Summation:5250934] The B-WICH complex is a large 3 Mdalton complex containing S...
updateTrackers	[UpdateTracker:9783170] Update Tracker - [Pathway:5250924] B-WICH complex positively regulates rRNA expression - v57:[updateContainedRLE] [UpdateTracker:9775988] Update Tracker - [Pathway:5250924] B-WICH complex positively regulates rRNA expression - v78:[updateContainedRLE] [UpdateTracker:9780589] Update Tracker - [Pathway:5250924] B-WICH complex positively regulates rRNA expression - v62:[modifyText]

Referrals

(updatedInstance)

[UpdateTracker:9783170] Update Tracker - [Pathway:5250924] B-WICH complex positively regulates rRNA expression - v57:[updateContainedRLE]
[UpdateTracker:9775988] Update Tracker - [Pathway:5250924] B-WICH complex positively regulates rRNA expression - v78:[updateContainedRLE]
[UpdateTracker:9780589] Update Tracker - [Pathway:5250924] B-WICH complex positively regulates rRNA expression - v62:[modifyText]

(hasEvent)

[Pathway:R-HSA-5250913] Positive epigenetic regulation of rRNA expression

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