By analogy to the process described for botulinum toxin type A (Koriazova and Montal 2003; Montal 2010), acidification, a normal step in synaptic vesicle recycling, is inferred to cause a conformational change in the botulinum toxin type D disulfide-bonded heavy chain - light chain dimer (botD HC:LC) it contains, allowing the HC part of the toxin to function as a channel through which its LC part is extruded into the neuronal cytosol where the HC - LC disulfide bond is cleaved.
Montal, M
Koriazova, LK, Montal, M
protein transmembrane transporter activity of botD:SV2:GD2 [synaptic vesicle membrane]
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