botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol

Stable Identifier
Reaction [omitted]
Homo sapiens
Related Species
Clostridium botulinum
Locations in the PathwayBrowser
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By analogy to the process described for botulinum toxin type A (Koriazova and Montal 2003; Montal 2010), acidification, a normal step in synaptic vesicle recycling, is inferred to cause a conformational change in the botulinum toxin type D disulfide-bonded heavy chain - light chain dimer (botD HC:LC) it contains, allowing the HC part of the toxin to function as a channel through which its LC part is extruded into the neuronal cytosol where the HC - LC disulfide bond is cleaved.

Literature References
PubMed ID Title Journal Year
20233039 Botulinum neurotoxin: a marvel of protein design

Montal, M

Annu. Rev. Biochem. 2010
12459720 Translocation of botulinum neurotoxin light chain protease through the heavy chain channel

Koriazova, LK, Montal, M

Nat Struct Biol 2003
Catalyst Activity

protein transmembrane transporter activity of botD:SV2:GD2 [synaptic vesicle membrane]

This event is regulated
Positively by
Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
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