Reactome | APC I1417 fs*2 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5246649] Rothfels, K, 2014-01-22
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575
dbId	5246651
disease	[Disease:4791250] colorectal cancer
displayName	APC I1417 fs*2 [cytosol]
endCoordinate	1417
hasModifiedResidue	[FragmentReplacedModification:5246657] Replacement of residues 1417 to 1417 by L
inDisease	true
maxDepth	1
memberOf	[CandidateSet:R-HSA-4791256] APC truncation mutants [cytosol] - Homo sapiens [DefinedSet:R-HSA-5246650] APC polyubiquitination mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:9967510] D'Eustachio, Peter, 2025-09-29
name	APC I1417 fs*2 Adenomatous polyposis coli protein APC_HUMAN DLD1
referenceEntity	[ReferenceGeneProduct:uniprot:P25054] UniProt:P25054 APC
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-5246651
startCoordinate	2
updateTrackers	[UpdateTracker:9972268] Update Tracker - [EntityWithAccessionedSequence:5246651] APC I1417 fs*2 [cytosol] - v95:[modifyStartCoordinate]

(updatedInstance)	[UpdateTracker:9972268] Update Tracker - [EntityWithAccessionedSequence:5246651] APC I1417 fs*2 [cytosol] - v95:[modifyStartCoordinate]
(hasMember)	[CandidateSet:R-HSA-4791256] APC truncation mutants [cytosol] [DefinedSet:R-HSA-5246650] APC polyubiquitination mutants [cytosol]

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