RANBP2 of the nuclear pore complex SUMOylates PML with SUMO1 at lysine-65, lysine-160, and lysine-490 (Sternsdorf et al. 1997, Kamitani et al. 1998, Duprez et al. 1999). SUMOylated PML is observed during interphase but not during mitosis (Everett et al. 1999). RANBP2 contains both a binding site for SUMO1 and a binding site for UBE2I (Tatham et al. 2005). The binding site for SUMO1 may play a role in SUMOylation of PML with SUMO1. Knockdown of RANBP2 reduces the number of PML bodies (Saitoh et al. 2006).
Galisson, F, Mahrouche, L, Courcelles, M, Bonneil, E, Meloche, S, Chelbi-Alix, MK, Thibault, P
Kamitani, T, Kito, K, Nguyen, HP, Wada, H, Fukuda-Kamitani, T, Yeh, ET
Kamitani, T, Nguyen, HP, Kito, K, Fukuda-Kamitani, T, Yeh, ET
Tatham, MH, Kim, S, Jaffray, E, Song, J, Chen, Y, Hay, RT
Sternsdorf, T, Jensen, K, Will, H
Saitoh, N, Uchimura, Y, Tachibana, T, Sugahara, S, Saitoh, H, Nakao, M
Duprez, E, Saurin, AJ, Desterro, JM, Lallemand-Breitenbach, V, Howe, K, Boddy, MN, Solomon, E, de Thé, H, Hay, RT, Freemont, PS
Everett, RD, Lomonte, P, Sternsdorf, T, van Driel, R, Orr, A
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