RANBP2 of the nuclear pore complex SUMOylates PML with SUMO1 at lysine-65, lysine-160, and lysine-490 (Sternsdorf et al. 1997, Kamitani et al. 1998, Duprez et al. 1999). SUMOylated PML is observed during interphase but not during mitosis (Everett et al. 1999). RANBP2 contains both a binding site for SUMO1 and a binding site for UBE2I (Tatham et al. 2005). The binding site for SUMO1 may play a role in SUMOylation of PML with SUMO1. Knockdown of RANBP2 reduces the number of PML bodies (Saitoh et al. 2006).
Wada, H, Kamitani, T, Yeh, ET, Fukuda-Kamitani, T, Nguyen, HP, Kito, K
Chelbi-Alix, MK, Meloche, S, Bonneil, E, Galisson, F, Courcelles, M, Thibault, P, Mahrouche, L
Kamitani, T, Yeh, ET, Fukuda-Kamitani, T, Nguyen, HP, Kito, K
Kim, S, Tatham, MH, Chen, Y, Hay, RT, Jaffray, E, Song, J
Sternsdorf, T, Will, H, Jensen, K
Nakao, M, Tachibana, T, Uchimura, Y, Saitoh, N, Saitoh, H, Sugahara, S
Lallemand-Breitenbach, V, de Thé, H, Freemont, PS, Duprez, E, Saurin, AJ, Desterro, JM, Solomon, E, Boddy, MN, Hay, RT, Howe, K
Sternsdorf, T, Orr, A, van Driel, R, Everett, RD, Lomonte, P
SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
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