Reactome | p-MAPK2/3 phosphorylates HSP27

Schema > BlackBoxEvent > Entries

p-MAPK2/3 phosphorylates HSP27 Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity	[CatalystActivity:5218918] protein serine/threonine kinase activity of p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643622] protein serine/threonine kinase activity of p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5218917] Garapati, P V, 2013-12-20
dbId	5218916
displayName	p-MAPK2/3 phosphorylates HSP27
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-5218769] HSP27 oligomer:F-actin [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5218673] Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2)-dependent phosphorylation of heat-shock protein of 27 kDa (Hsp27)
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	p-MAPK2/3 phosphorylates HSP27
orthologousEvent	[BlackBoxEvent:R-CEL-5218916] p-MAPK2/3 phosphorylates HSP27 - Caenorhabditis elegans [BlackBoxEvent:R-DME-5218916] p-MAPK2/3 phosphorylates HSP27 - Drosophila melanogaster [BlackBoxEvent:R-GGA-5218916] p-MAPK2/3 phosphorylates HSP27 - Gallus gallus [BlackBoxEvent:R-DRE-5218916] p-MAPK2/3 phosphorylates HSP27 - Danio rerio [BlackBoxEvent:R-SSC-5218916] p-MAPK2/3 phosphorylates HSP27 - Sus scrofa [BlackBoxEvent:R-BTA-5218916] p-MAPK2/3 phosphorylates HSP27 - Bos taurus [BlackBoxEvent:R-RNO-5218916] p-MAPK2/3 phosphorylates HSP27 - Rattus norvegicus [BlackBoxEvent:R-MMU-5218916] p-MAPK2/3 phosphorylates HSP27 - Mus musculus
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Polymer:R-HSA-201877] F-actin [cytosol] [EntityWithAccessionedSequence:R-HSA-5218697] p-S15,S78,S82-HSP27 [cytosol]
precedingEvent	[Reaction:R-HSA-187688] p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5218916
summation	[Summation:5218420] Activated MAP kinase-activated protein kinase (MAPK/MAPKAPK)...

Referrals

(hasEvent)

[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway