p-MAPK2/3 phosphorylates HSP27

Stable Identifier
R-HSA-5218916
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Activated MAP kinase-activated protein kinase (MAPK/MAPKAPK) 2 and 3 in turn phosphorylate heat shock protein beta 1 (HSPB1, HSP27). HSP27 is an actin-capping protein. Its phosphorylation has been proposed to release it from actin filaments, thus allowing addition of actin monomers and elongation of filaments. Phosphorylation-induced conformational changes causes disaggregation of oligomeric complexes of HSP27 and subsequent disassociation from actin filaments, which may result in a higher rate of actin polymerization (Lamalice et al. 2007, Rousseau et al. 2000, Lavoie et al. 1995).

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Catalyst Activity
Title
protein serine/threonine kinase activity of p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol]
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Activity
Orthologous Events
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