Endocytosis of EF:LF:PA63:ANTXR2 (plasma membrane to endosome membrane)

Stable Identifier
R-HSA-5210959
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
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Anthrax EF (edema factor) and LF (lethal factor) toxins bound to PA63:ANTXR2 (protective antigen, large fragment: Anthrax receptor 2) oligomer on the plasma membrane of the target cell, are localized into clathrin coated vesicles and transported to endosomes (Abrami et al. 2003). Depletion of target cell ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3) partly blocks endocytosis (Lu et al. 2004), but this effect may be indirect and has not been characterized at a molecular level (van der Goot & Young 2009).

Literature References
PubMed ID Title Journal Year
15569923 EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin

Lu, Q, Wei, W, Kowalski, PE, Chang, AC, Cohen, SN

Proc. Natl. Acad. Sci. U.S.A. 2004
12551953 Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

Abrami, L, Liu, S, Cosson, P, Leppla, SH, van der Goot, FG

J. Cell Biol. 2003
19732789 Receptors of anthrax toxin and cell entry

van der Goot, FG, Young, JA

Mol. Aspects Med. 2009
Participants
Participant Of
Disease
Name Identifier Synonyms
anthrax disease 7427
Authored
Reviewed
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