cya and lef bind to pagA(197-794):ANTXR1 oligomer

Stable Identifier
R-HSA-5210923
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
cya and lef bind to pagA(197-794):ANTXR1 oligomer
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The enzyme components of anthrax toxins cya (also known as EF, Edema Factor - Robertson et al. 1988) and lef (also known as LF, Lethal Factor - Bragg & Robertson 1989; Klimpel et al. 1994) bind to pagA(197-794):ANTXR1 (protective antigen, large fragment: Anthrax receptor 1) oligomers on the target cell surface. Binding of the two toxins to an oligomer is competitive and as many as four toxin molecules can bind to one oligomer (Elliott et al. 2000; Pimental et al. 2004).
Literature References
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Cross References
Mondo
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Liu, S  (2014-05-28)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Created
D'Eustachio, P  (2013-12-07)
Cite Us!