Furin cleaves ANTXR2-bound PA83 to yield PA63

Stable Identifier
R-HSA-5210912
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
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Furin or a related protease at the cell surface cleaves ANTXR2-bound PA83 (Anthrax protective antigen, full length) to yield PA63. The larger cleavage product, PA63, remains bound to the receptor while a smaller product, PA20, is released into the extracellular space (Klimpel et al, 1992; Koo et al. 2006; Molloy et al. 1992).

Literature References
PubMed ID Title Journal Year
1438214 Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

Klimpel, KR, Molloy, S S, Thomas, G, Leppla, SH

Proc. Natl. Acad. Sci. U.S.A. 1992
1644824 Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen

Molloy, S S, Bresnahan, PA, Leppla, SH, Klimpel, KR, Thomas, G

J. Biol. Chem. 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of FURIN [plasma membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
anthrax disease 7427
Authored
Reviewed
Created
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