Reactome | Signaling by AXIN mutants

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Signaling by AXIN mutants Show undefined attributes

authored	[InstanceEdit:4839725] Rothfels, K, 2013-11-01
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4839736] Rothfels, K, 2013-11-02
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	4839735
disease	[Disease:1500689] cancer
displayName	Signaling by AXIN mutants
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
eventOf	[Pathway:R-HSA-4791275] Signaling by WNT in cancer - Homo sapiens
figure	[Figure:9758321] /figures/ehld/R-HSA-4839735.svg
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-5467345] Deletions in the AXIN1 gene destabilize the destruction complex - Homo sapiens [Pathway:R-HSA-5467340] AXIN missense mutants destabilize the destruction complex - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2015-03-23
literatureReference	[LiteratureReference:3238089] The way Wnt works: Components and mechanism [LiteratureReference:5251469] AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 [LiteratureReference:5251510] Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas [LiteratureReference:5251479] Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability [LiteratureReference:5251481] Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas [LiteratureReference:5251535] The links between axin and carcinogenesis
maxDepth	3
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Signaling by AXIN mutants
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4839735
summation	[Summation:5251519] AXIN1 and AXIN2 are critical scaffolding proteins of the bet...
updateTrackers	[UpdateTracker:9785001] Update Tracker - [Pathway:4839735] Signaling by AXIN mutants - v52:[removeHasEvent, updateContainedPathway, updateIndirectRLE]

Referrals

(updatedInstance)	[UpdateTracker:9785001] Update Tracker - [Pathway:4839735] Signaling by AXIN mutants - v52:[removeHasEvent, updateContainedPathway, updateIndirectRLE]
(hasEvent)	[Pathway:R-HSA-4791275] Signaling by WNT in cancer