AXIN1 and AXIN2 are critical scaffolding proteins of the bet...

created [InstanceEdit:5251518] Rothfels, K, 2014-02-04
dbId 5251519
displayName AXIN1 and AXIN2 are critical scaffolding proteins of the bet...
modified [InstanceEdit:5545633] Rothfels, Karen, 2014-05-22
schemaClass Summation
text AXIN1 and AXIN2 are critical scaffolding proteins of the beta-catenin destruction complex and make protein-protein interactions with several of the other complex components including APC, GSK3, CK1 and beta-catenin itself through specific domains (reviewed in Saito-Diaz et al, 2013). Because of its role in promoting the degradation of beta-catenin and thereby restricting WNT signaling, AXIN1 is regarded as a tumor suppressor; consistent with this, biallelic mutations in AXIN1 that abrogate its expression or result in the production of truncated proteins have been identified in some human cancers, notably in hepatocellular and colorectal carcinomas and medullobalstoma (Satoh et al, 2000; Taniguchi et al, 2002; Shimizu et al, 2002; Dahmen et al, 2001; reviewed in Salahshor and Woodgett, 2005).
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