Reactome | HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3

HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3

Stable Identifier

R-HSA-4720432

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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HDAC4 SUMOylates NR1H2 (LXR-beta) with SUMO2,3 at lysine-409 and lysine-447 (lysine-410 and lysine-448 of the isoform used by Ghisletti et al. 2007) (Venteclef et al. 2010). SUMOylation is enhanced when NR1H2 binds specific oxysterols and causes NR1H2 to recruit the NCOR repressor and transrepress promoters such as iNOS.

Literature References

PubMed ID	Title	Journal	Year
20159957	GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response Venteclef, N, Jakobsson, T, Ehrlund, A, Damdimopoulos, A, Mikkonen, L, Ellis, E, Nilsson, LM, Parini, P, Jänne, OA, Gustafsson, JA, Steffensen, KR, Treuter, E	Genes Dev.	2010
17218271	Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma Ghisletti, S, Huang, W, Ogawa, S, Pascual, G, Lin, ME, Willson, TM, Rosenfeld, MG, Glass, CK	Mol. Cell	2007