Reactome | Defective DPM3 does not transfer mannose to DOLP to form DOLPman

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Defective DPM3 does not transfer mannose to DOLP to form DOLPman Show undefined attributes

authored	[InstanceEdit:4719380] Jassal, B, 2013-10-18
catalystActivity	[CatalystActivity:9631797] dolichyl-phosphate beta-D-mannosyltransferase activity of DPM1:DPM2:DPM3 L85S [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:5263266] cytoplasmic side of endoplasmic reticulum membrane
created	[InstanceEdit:4719368] Jassal, B, 2013-10-18
crossReference	[DatabaseIdentifier:12020873] Mondo:0005500
dbId	4719354
disease	[Disease:3781892] congenital disorder of glycosylation type I
displayName	Defective DPM3 does not transfer mannose to DOLP to form DOLPman
edited	[InstanceEdit:4719380] Jassal, B, 2013-10-18
entityFunctionalStatus	[EntityFunctionalStatus:4719353] loss_of_function of DPM1:DPM2:DPM3 L85S [endoplasmic reticulum membrane]
eventOf	[Pathway:R-HSA-4719360] Defective DPM3 causes DPM3-CDG - Homo sapiens
input	[SimpleEntity:R-ALL-449744] DOLDP [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-162860] GDP-Man [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:162702] Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3 [LiteratureReference:4719349] Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies
maxDepth	1
modified	[InstanceEdit:9910684] D'Eustachio, Peter, 2024-05-16
name	Defective DPM3 does not transfer mannose to DOLP to form DOLPman
normalReaction	[Reaction:R-HSA-162721] dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690642] Spillmann, Dorothe, 2015-04-30
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4719354
summation	[Summation:4719351] Dolichyl-phosphate mannosyltransferase (DPM), a heterotrimer...
updateTrackers	[UpdateTracker:9778056] Update Tracker - [FailedReaction:4719354] Defective DPM3 does not transfer mannose to DOLP to form DOLPman - v68:[addCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9778056] Update Tracker - [FailedReaction:4719354] Defective DPM3 does not transfer mannose to DOLP to form DOLPman - v68:[addCatalystActivity]
(hasEvent)	[Pathway:R-HSA-4719360] Defective DPM3 causes DPM3-CDG

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