Reactome | Defective DPM3 causes DPM3-CDG

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Defective DPM3 causes DPM3-CDG Show undefined attributes

authored	[InstanceEdit:4719380] Jassal, B, 2013-10-18
created	[InstanceEdit:4719368] Jassal, B, 2013-10-18
crossReference	[DatabaseIdentifier:12020873] Mondo:0005500
dbId	4719360
disease	[Disease:3781892] congenital disorder of glycosylation type I
displayName	Defective DPM3 causes DPM3-CDG
edited	[InstanceEdit:4719380] Jassal, B, 2013-10-18
eventOf	[Pathway:R-HSA-5609975] Diseases associated with glycosylation precursor biosynthesis - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-4719354] Defective DPM3 does not transfer mannose to DOLP to form DOLPman - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:162702] Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3 [LiteratureReference:4719349] Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Defective DPM3 causes DPM3-CDG Defective DPM3 causes CDG-1o
normalPathway	[Pathway:R-HSA-446203] Asparagine N-linked glycosylation
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690642] Spillmann, Dorothe, 2015-04-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4719360
summation	[Summation:4719369] Dolichyl-phosphate mannosyltransferase (DPM), a heterotrimer...
updateTrackers	[UpdateTracker:9778014] Update Tracker - [Pathway:4719360] Defective DPM3 causes DPM3-CDG - v68:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9778014] Update Tracker - [Pathway:4719360] Defective DPM3 causes DPM3-CDG - v68:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-5609975] Diseases associated with glycosylation precursor biosynthesis

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