DVL1 is bound by the HECT ubiquitin ligase HECW1

Stable Identifier
R-HSA-4641155
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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DVL1 is bound by the HECT ubiquitin ligase HECW1
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HECW1, also known as NEDL1, is an HECT E3 ligase that co-immunoprecipitates with DVL1 upon cotransfection in Neuro2 cells and targets it for proteasomal degradation (Miyazaki et al, 2004).
Literature References
PubMed ID Title Journal Year
14684739 NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1

Miyazaki, K, Aoki, M, Itoyama, Y, Ozaki, T, Goto, T, Kurose, Y, Fujita, T, Kato, S, Kato, C, Nakagawara, A, Sakamoto, M

J. Biol. Chem. 2004
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Orthologous Events
DVL1 is bound by the HECT ubiquitin ligase HECW1 (Bos taurus)
DVL1 is bound by the HECT ubiquitin ligase HECW1 (Caenorhabditis elegans)
DVL1 is bound by the HECT ubiquitin ligase HECW1 (Canis familiaris)
DVL1 is bound by the HECT ubiquitin ligase HECW1 (Drosophila melanogaster)
DVL1 is bound by the HECT ubiquitin ligase HECW1 (Mus musculus)
DVL1 is bound by the HECT ubiquitin ligase HECW1 (Rattus norvegicus)
DVL1 is bound by the HECT ubiquitin ligase HECW1 (Sus scrofa)
Authored
Rothfels, K  (2013-09-23)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2013-09-28)
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