Reactome | Translocation of NFATC1:CaN:CaM to nucleus

Translocation of NFATC1:CaN:CaM to nucleus

Stable Identifier

R-HSA-4551465

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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Translocation of NFATC1:CaN:CaM to nucleus

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Dephosphorylated NFAT-calcineurin (CaN) complex translocates to nucleus, where it activates transcription (Okamura et al, 2000; Demjek et al, 2006; Saneyoshi et al, 2002; reviewed in Hogan et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
11030334	Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity Zhang, X, Rao, A, Viola, JP, Okamura, H, Hogan, PG, Tahiliani, M, Aramburu, J, García-Rodríguez, C, Qin, J, Raghavan, A	Mol Cell	2000
16880514	Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells Säfholm, A, Dejmek, J, Leandersson, K, Andersson, T, Kamp Nielsen, C	Mol. Cell. Biol.	2006
12975316	Transcriptional regulation by calcium, calcineurin, and NFAT Hogan, PG, Rao, A, Nardone, J, Chen, L	Genes Dev.	2003
12015605	The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos Kume, S, Amasaki, Y, Saneyoshi, T, Mikoshiba, K	Nature	2002