Translocation of NFATC1:CaN:CaM to nucleus

Stable Identifier
R-HSA-4551465
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Dephosphorylated NFAT-calcineurin (CaN) complex translocates to nucleus, where it activates transcription (Okamura et al, 2000; Demjek et al, 2006; Saneyoshi et al, 2002; reviewed in Hogan et al, 2003).

Literature References
PubMed ID Title Journal Year
16880514 Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells

Dejmek, J, Säfholm, A, Kamp Nielsen, C, Andersson, T, Leandersson, K

Mol. Cell. Biol. 2006
11030334 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

Okamura, H, Aramburu, J, García-Rodríguez, C, Viola, JP, Raghavan, A, Tahiliani, M, Zhang, X, Qin, J, Hogan, PG, Rao, A

Mol Cell 2000
12975316 Transcriptional regulation by calcium, calcineurin, and NFAT

Hogan, PG, Chen, L, Nardone, J, Rao, A

Genes Dev. 2003
12015605 The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos

Saneyoshi, T, Kume, S, Amasaki, Y, Mikoshiba, K

Nature 2002
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