Translocation of NFATC1:CaN:CaM to nucleus

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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Dephosphorylated NFAT-calcineurin (CaN) complex translocates to nucleus, where it activates transcription (Okamura et al, 2000; Demjek et al, 2006; Saneyoshi et al, 2002; reviewed in Hogan et al, 2003).

Literature References
PubMed ID Title Journal Year
11030334 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

Zhang, X, Rao, A, Viola, JP, Okamura, H, Hogan, PG, Tahiliani, M, Aramburu, J, García-Rodríguez, C, Qin, J, Raghavan, A

Mol Cell 2000
16880514 Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells

Säfholm, A, Dejmek, J, Leandersson, K, Andersson, T, Kamp Nielsen, C

Mol. Cell. Biol. 2006
12975316 Transcriptional regulation by calcium, calcineurin, and NFAT

Hogan, PG, Rao, A, Nardone, J, Chen, L

Genes Dev. 2003
12015605 The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos

Kume, S, Amasaki, Y, Saneyoshi, T, Mikoshiba, K

Nature 2002
Orthologous Events
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