PIAS1,3 SUMOylates NR5A1 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIAS1,3 SUMOylate NR5A1 (Steroidogenic factor 1, SF1, SF-1) at lysine-119 and lysine-194 with SUMO1 (Chen et al. 2004, Komatsu et al. 2004, Suda et al. 2011). SUMOylation reduces the synergistic activation of SOX9 by NR5A1.

Literature References
PubMed ID Title Journal Year
21467194 Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1

Nakagawa, K, Shibata, H, Murai-Takeda, A, Kurihara, I, Yokota, K, Ikeda, Y, Rainey, WE, Saruta, T, Kobayashi, S, Itoh, H, Murai, M, Suda, N, Oya, M

Endocrinology 2011
15192080 Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9

Shirakawa, M, Baba, D, Kikuchi, A, Mukai, T, Komatsu, T, Mizusaki, H, Hatakeyama, S, Nakayama, KI, Ogawa, H, Yamamoto, H, Morohashi, K

Mol. Endocrinol. 2004
15192092 SUMO modification of repression domains modulates function of nuclear receptor 5A1 (steroidogenic factor-1)

Hsu, NC, Lee, WC, Chung, BC, Huang, F, Chen, WY

J. Biol. Chem. 2004
Catalyst Activity

SUMO transferase activity of PIAS1,3 [nucleoplasm]

Orthologous Events
Cite Us!