Reactome | IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane]

catalystActivities	[CatalystActivity:507940] protein tyrosine kinase activity of IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-452097] Recruited STAT5 is phosphorylated - Homo sapiens
created	[InstanceEdit:452117] Jupe, S, 2010-01-15
dbId	452107
displayName	IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane]
hasComponent	[Complex:R-HSA-452119] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] [DefinedSet:R-HSA-452094] STAT5A,STAT5B [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - Mus musculus [Complex:R-RNO-452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - Canis familiaris [Complex:R-BTA-452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - Bos taurus [Complex:R-SSC-452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - Sus scrofa
isChimeric	false
maxDepth	4
modified	[InstanceEdit:919403] Jupe, S, 2010-08-04
name	IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5
producedByEvent	[Reaction:R-HSA-452108] Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-452107
updateTrackers	[UpdateTracker:9897318] Update Tracker - [Complex:452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - v61:[updateContainedComponent] [UpdateTracker:9872477] Update Tracker - [Complex:452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - v41:[updateContainedComponent] [UpdateTracker:9871053] Update Tracker - [Complex:452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - v39:[updateContainedComponent]

IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] Show undefined attributes

Referrals

(updatedInstance)	[UpdateTracker:9897318] Update Tracker - [Complex:452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - v61:[updateContainedComponent] [UpdateTracker:9872477] Update Tracker - [Complex:452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - v41:[updateContainedComponent] [UpdateTracker:9871053] Update Tracker - [Complex:452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - v39:[updateContainedComponent]
(output)	[Reaction:R-HSA-452108] Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
(input)	[Reaction:R-HSA-452097] Recruited STAT5 is phosphorylated
(physicalEntity)	[CatalystActivity:507940] protein tyrosine kinase activity of IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane]