Reactome | IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10142182] protein tyrosine kinase activity of IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-RNO-452097] Recruited STAT5 is phosphorylated - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10142172
displayName	IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane]
hasComponent	[Complex:R-RNO-452119] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] [DefinedSet:R-RNO-452094] STAT5A,STAT5B [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] - Homo sapiens
maxDepth	4
name	IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5
producedByEvent	[Reaction:R-RNO-452108] Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-452107
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-RNO-452097] Recruited STAT5 is phosphorylated
(physicalEntity)	[CatalystActivity:10142182] protein tyrosine kinase activity of IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane]
(output)	[Reaction:R-RNO-452108] Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
(inferredTo)	[Complex:R-HSA-452107] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane]

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