Reactome | HuR binds the CRM1 nuclear export machinery

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HuR binds the CRM1 nuclear export machinery Show undefined attributes

authored	[InstanceEdit:451187] May, B, 2009-12-29
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:450588] May, B, 2009-12-16
dbId	450387
displayName	HuR binds the CRM1 nuclear export machinery
edited	[InstanceEdit:451187] May, B, 2009-12-29
eventOf	[Pathway:R-HSA-450520] HuR (ELAVL1) binds and stabilizes mRNA - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-450595] HuR:mRNA complex translocates from the nucleus to the cytosol - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-450467] ANP32A [nucleoplasm] [DefinedSet:R-HSA-517615] HuR:mRNA complexes [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-451222] NUP214 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-450603] p-T243-TNFSF13 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-451201] SET [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-165529] XPO1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450478] Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression [LiteratureReference:451110] Protein ligands to HuR modulate its interaction with target mRNAs in vivo [LiteratureReference:517721] Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	HuR binds the CRM1 nuclear export machinery
orthologousEvent	[Reaction:R-DME-450387] HuR binds the CRM1 nuclear export machinery - Drosophila melanogaster [Reaction:R-SSC-450387] HuR binds the CRM1 nuclear export machinery - Sus scrofa [Reaction:R-BTA-450387] HuR binds the CRM1 nuclear export machinery - Bos taurus [Reaction:R-CFA-450387] HuR binds the CRM1 nuclear export machinery - Canis familiaris [Reaction:R-RNO-450387] HuR binds the CRM1 nuclear export machinery - Rattus norvegicus [Reaction:R-MMU-450387] HuR binds the CRM1 nuclear export machinery - Mus musculus
output	[Complex:R-HSA-450537] HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-450494] HuR binds mRNAs in the nucleus - Homo sapiens [Reaction:R-HSA-517674] p-S158,221-HuR binds mRNA - Homo sapiens [Reaction:R-HSA-517705] p-S318,221-HuR binds mRNA - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:882027] Wilusz, J, 2010-06-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450387
summation	[Summation:451100] HuR interacts with SETalpha (Template activating factor 1), ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-450595] HuR:mRNA complex translocates from the nucleus to the cytosol
(hasEvent)	[Pathway:R-HSA-450520] HuR (ELAVL1) binds and stabilizes mRNA