Reactome | Phosphorylation of MEF2 proteins by p38

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Phosphorylation of MEF2 proteins by p38 Show undefined attributes

authored	[InstanceEdit:375169] Garapati, P V, 2008-08-11 10:36:48
catalystActivity	[CatalystActivity:448950] protein serine/threonine kinase activity of phospho-p38 alpha/beta/gamma MAPK [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:448956] Garapati, P V, 2009-11-26
dbId	448955
displayName	Phosphorylation of MEF2 proteins by p38
edited	[InstanceEdit:375169] Garapati, P V, 2008-08-11 10:36:48
eventOf	[Pathway:R-HSA-525793] Myogenesis - Homo sapiens
followingEvent	[Reaction:R-HSA-448963] Interaction of MyoD:E protein with MEF2 - Homo sapiens
input	5 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-HSA-448868] MEF2 proteins [nucleoplasm] [DefinedSet:R-HSA-448858] phospho-p38 alpha/beta/gamma MAPK [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:448932] Regulation of the MEF2 family of transcription factors by p38 [LiteratureReference:448930] Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors [LiteratureReference:448936] p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps [LiteratureReference:448894] Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation [LiteratureReference:448906] p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Phosphorylation of MEF2 proteins by p38
orthologousEvent	[Reaction:R-SCE-448955] Phosphorylation of MEF2 proteins by p38 - Saccharomyces cerevisiae [Reaction:R-SPO-448955] Phosphorylation of MEF2 proteins by p38 - Schizosaccharomyces pombe [Reaction:R-DDI-448955] Phosphorylation of MEF2 proteins by p38 - Dictyostelium discoideum [Reaction:R-CEL-448955] Phosphorylation of MEF2 proteins by p38 - Caenorhabditis elegans [Reaction:R-DME-448955] Phosphorylation of MEF2 proteins by p38 - Drosophila melanogaster [Reaction:R-GGA-448955] Phosphorylation of MEF2 proteins by p38 - Gallus gallus [Reaction:R-XTR-448955] Phosphorylation of MEF2 proteins by p38 - Xenopus tropicalis [Reaction:R-SSC-448955] Phosphorylation of MEF2 proteins by p38 - Sus scrofa [Reaction:R-BTA-448955] Phosphorylation of MEF2 proteins by p38 - Bos taurus [Reaction:R-RNO-448955] Phosphorylation of MEF2 proteins by p38 - Rattus norvegicus [Reaction:R-MMU-448955] Phosphorylation of MEF2 proteins by p38 - Mus musculus
output	5 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-448874] phospho p38:phospho MEF2 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-448958] Nuclear translocation of p38 MAPK - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:507894] Krauss, RS, 2010-02-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-448955
summation	[Summation:448807] The family of transcription factors myocyte enhancer factor-...

Referrals

(hasEvent)	[Pathway:R-HSA-525793] Myogenesis
(precedingEvent)	[Reaction:R-HSA-448963] Interaction of MyoD:E protein with MEF2