Reactome | GAT1-3 mediate Na+/Cl- dependent GABA transport

Schema > Reaction > Entries

GAT1-3 mediate Na+/Cl- dependent GABA transport Show undefined attributes

authored	[InstanceEdit:444041] Jassal, Bijay, 2009-10-20
catalystActivity	[CatalystActivity:444014] gamma-aminobutyric acid:sodium:chloride symporter activity of SLC6A GABA transporters [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:444041] Jassal, Bijay, 2009-10-20
crossReference	[DatabaseIdentifier:12667464] RHEA:70687 [DatabaseIdentifier:9956804] RHEA:70688
dbId	444007
displayName	GAT1-3 mediate Na+/Cl- dependent GABA transport
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
eventOf	[Pathway:R-HSA-442660] SLC-mediated transport of neurotransmitters - Homo sapiens
followingEvent	[Reaction:R-HSA-428625] Vesicular inhibitory amino acid transport - Homo sapiens [BlackBoxEvent:R-HSA-9653180] GABA translocates from cytosol to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen - Homo sapiens
input	[SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-352003] GABA [extracellular region] 2 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:444034] Cloning of the human brain GABA transporter [LiteratureReference:444023] Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2 [LiteratureReference:444013] Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site [LiteratureReference:444016] Role of Cl- in electrogenic Na+-coupled cotransporters GAT1 and SGLT1
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	GAT1-3 mediate Na+/Cl- dependent GABA transport
orthologousEvent	[Reaction:R-PFA-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Plasmodium falciparum [Reaction:R-CEL-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Caenorhabditis elegans [Reaction:R-DME-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Drosophila melanogaster [Reaction:R-GGA-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Gallus gallus [Reaction:R-XTR-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Xenopus tropicalis [Reaction:R-DRE-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Danio rerio [Reaction:R-SSC-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Sus scrofa [Reaction:R-BTA-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Bos taurus [Reaction:R-CFA-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Canis familiaris [Reaction:R-RNO-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Rattus norvegicus [Reaction:R-MMU-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Mus musculus
output	[SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-352011] GABA [cytosol] 2 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12
revised	[InstanceEdit:918281] Mahajan, SS, 2010-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-444007
summation	[Summation:444003] Four transporters mediate GABA uptake in the brain, GAT1-3 a...

Referrals

(precedingEvent)	[Reaction:R-HSA-428625] Vesicular inhibitory amino acid transport [BlackBoxEvent:R-HSA-9653180] GABA translocates from cytosol to mitochondrial matrix [Reaction:R-HSA-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen
(hasEvent)	[Pathway:R-HSA-442660] SLC-mediated transport of neurotransmitters [Pathway:R-HSA-888593] Reuptake of GABA

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