Four transporters mediate GABA uptake in the brain, GAT1-3 and BGT1. They terminates the action of GABA by high affinity sodium-dependent reuptake into presynaptic terminals. Transport of GABA by GAT1-3 is proposed to be accompanied by 2Na+ ions and 1 Cl- ion (Loo DD et al, 2000).SLC6A1 encodes a sodium- and chloride-dependent GABA transporter 1, GAT1, which is the predominant GABA transporter in brain. It is widely distributed in the brain and co-localized to GABAergic neurons (Nelson H et al, 1990). SLC6A13 encodes a sodium- and chloride-dependent GABA transporter 2, GAT2, which is localized to GABAergic neurons in the brain. It is also found in retina, liver and kidney (Christiansen B et al, 2007). SLC6A11 encodes a sodium- and chloride-dependent GABA transporter 3, GAT3. It is expressed in the brain and localizes to GABAergic neurons (Borden LA et al, 1994).
Weinshank, RL, Borden, LA, Gluchowski, C, Branchek, TA, Dhar, TG, Smith, KE
Sarkar, HK, Eskandari, S, Loo, DD, Boorer, KJ, Wright, EM
Nelson, N, Mandiyan, S, Nelson, H
Jensen, AA, Meinild, AK, Braüner-Osborne, H, Christiansen, B
gamma-aminobutyric acid:sodium symporter activity of SLC6A GABA transporters [plasma membrane]
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