GAT1-3 mediate Na+/Cl- dependent GABA transport

Stable Identifier
R-HSA-444007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Four transporters mediate GABA uptake in the brain, GAT1-3 and BGT1. They terminates the action of GABA by high affinity sodium-dependent reuptake into presynaptic terminals. Transport of GABA by GAT1-3 is proposed to be accompanied by 2Na+ ions and 1 Cl- ion (Loo DD et al, 2000).

SLC6A1 encodes a sodium- and chloride-dependent GABA transporter 1, GAT1, which is the predominant GABA transporter in brain. It is widely distributed in the brain and co-localized to GABAergic neurons (Nelson H et al, 1990). SLC6A13 encodes a sodium- and chloride-dependent GABA transporter 2, GAT2, which is localized to GABAergic neurons in the brain. It is also found in retina, liver and kidney (Christiansen B et al, 2007). SLC6A11 encodes a sodium- and chloride-dependent GABA transporter 3, GAT3. It is expressed in the brain and localizes to GABAergic neurons (Borden LA et al, 1994).

Literature References
PubMed ID Title Journal Year
10973981 Role of Cl- in electrogenic Na+-coupled cotransporters GAT1 and SGLT1

Loo, DD, Eskandari, S, Boorer, KJ, Sarkar, HK, Wright, EM

J Biol Chem 2000
7874447 Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site

Borden, LA, Dhar, TG, Smith, KE, Branchek, TA, Gluchowski, C, Weinshank, RL

Receptors Channels 1994
2387399 Cloning of the human brain GABA transporter

Nelson, H, Mandiyan, S, Nelson, N

FEBS Lett 1990
17502375 Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2

Christiansen, B, Meinild, AK, Jensen, AA, Bra√ľner-Osborne, H

J Biol Chem 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
gamma-aminobutyric acid:sodium symporter activity of SLC6A GABA transporters [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created