GAT1-3 mediate Na+/Cl- dependent GABA transport

Stable Identifier
R-HSA-444007
Type
Reaction
Species
Homo sapiens
Compartment
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Four transporters mediate GABA uptake in the brain, GAT1-3 and BGT1. They terminates the action of GABA by high affinity sodium-dependent reuptake into presynaptic terminals. Transport of GABA by GAT1-3 is proposed to be accompanied by 2Na+ ions and 1 Cl- ion (Loo DD et al, 2000).

SLC6A1 encodes a sodium- and chloride-dependent GABA transporter 1, GAT1, which is the predominant GABA transporter in brain. It is widely distributed in the brain and co-localized to GABAergic neurons (Nelson H et al, 1990). SLC6A13 encodes a sodium- and chloride-dependent GABA transporter 2, GAT2, which is localized to GABAergic neurons in the brain. It is also found in retina, liver and kidney (Christiansen B et al, 2007). SLC6A11 encodes a sodium- and chloride-dependent GABA transporter 3, GAT3. It is expressed in the brain and localizes to GABAergic neurons (Borden LA et al, 1994).

Literature References
PubMed ID Title Journal Year
7874447 Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site

Weinshank, RL, Borden, LA, Gluchowski, C, Branchek, TA, Dhar, TG, Smith, KE

Receptors Channels 1994
10973981 Role of Cl- in electrogenic Na+-coupled cotransporters GAT1 and SGLT1

Sarkar, HK, Eskandari, S, Loo, DD, Boorer, KJ, Wright, EM

J Biol Chem 2000
2387399 Cloning of the human brain GABA transporter

Nelson, N, Mandiyan, S, Nelson, H

FEBS Lett 1990
17502375 Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2

Jensen, AA, Meinild, AK, Bra√ľner-Osborne, H, Christiansen, B

J Biol Chem 2007
Participants
Participates
Catalyst Activity

gamma-aminobutyric acid:sodium symporter activity of SLC6A GABA transporters [plasma membrane]

Orthologous Events
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