Reactome | GAT1-3 mediate Na+/Cl- dependent GABA transport

GAT1-3 mediate Na+/Cl- dependent GABA transport

Stable Identifier

R-HSA-444007

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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GAT1-3 mediate Na+/Cl- dependent GABA transport

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Four transporters mediate GABA uptake in the brain, GAT1-3 and BGT1. They terminates the action of GABA by high affinity sodium-dependent reuptake into presynaptic terminals. Transport of GABA by GAT1-3 is proposed to be accompanied by 2Na+ ions and 1 Cl- ion (Loo DD et al, 2000).

SLC6A1 encodes a sodium- and chloride-dependent GABA transporter 1, GAT1, which is the predominant GABA transporter in brain. It is widely distributed in the brain and co-localized to GABAergic neurons (Nelson H et al, 1990). SLC6A13 encodes a sodium- and chloride-dependent GABA transporter 2, GAT2, which is localized to GABAergic neurons in the brain. It is also found in retina, liver and kidney (Christiansen B et al, 2007). SLC6A11 encodes a sodium- and chloride-dependent GABA transporter 3, GAT3. It is expressed in the brain and localizes to GABAergic neurons (Borden LA et al, 1994).

Literature References

PubMed ID	Title	Journal	Year
7874447	Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site Weinshank, RL, Borden, LA, Gluchowski, C, Branchek, TA, Dhar, TG, Smith, KE	Receptors Channels	1994
10973981	Role of Cl- in electrogenic Na+-coupled cotransporters GAT1 and SGLT1 Sarkar, HK, Eskandari, S, Loo, DD, Boorer, KJ, Wright, EM	J Biol Chem	2000
2387399	Cloning of the human brain GABA transporter Nelson, N, Mandiyan, S, Nelson, H	FEBS Lett	1990
17502375	Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2 Jensen, AA, Meinild, AK, Braüner-Osborne, H, Christiansen, B	J Biol Chem	2007