Reactome | GAT1-3 mediate Na+/Cl- dependent GABA transport

Schema > Reaction > Entries

GAT1-3 mediate Na+/Cl- dependent GABA transport Show undefined attributes

catalystActivity	[CatalystActivity:10938522] gamma-aminobutyric acid:sodium:chloride symporter activity of SLC6A GABA transporters [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10938524
displayName	GAT1-3 mediate Na+/Cl- dependent GABA transport
eventOf	[Pathway:R-CEL-442660] SLC-mediated transport of neurotransmitters - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-428625] Vesicular inhibitory amino acid transport - Caenorhabditis elegans [Reaction:R-CEL-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Homo sapiens
input	[SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-352003] GABA [extracellular region] 2 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	GAT1-3 mediate Na+/Cl- dependent GABA transport
output	[SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-352011] GABA [cytosol] 2 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-444007
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-442660] SLC-mediated transport of neurotransmitters [Pathway:R-CEL-888593] Reuptake of GABA
(precedingEvent)	[Reaction:R-CEL-428625] Vesicular inhibitory amino acid transport [Reaction:R-CEL-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen
(inferredTo)	[Reaction:R-HSA-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport