Reactome | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde

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CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Show undefined attributes

authored	[InstanceEdit:445353] Mahajan, SS, 2009-10-29
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:442716] Mahajan, SS, 2009-09-29
crossReference	[DatabaseIdentifier:12819497] BioModels Database:BIOMD0000000467 [DatabaseIdentifier:12819463] BioModels Database:BIOMD0000000088 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468
dbId	442729
deleted	[Deleted:9628529] Deletion of instance: 442717 [Deleted:9628808] Deletion of instance: 442745
displayName	CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
edited	[InstanceEdit:447013] Gillespie, ME, 2009-11-19 [InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
eventOf	[Pathway:R-HSA-438064] Post NMDA receptor activation events - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:645] chemical synaptic transmission
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-444792] Calmodulin-bound CaMKII-gamma enters the nucleus - Homo sapiens [Reaction:R-HSA-9618834] Activated calmodulin dissociates from CaMKII-gamma - Homo sapiens [Reaction:R-HSA-9618863] CaMKK binds activated calmodulin in the nucleus - Homo sapiens [Reaction:R-HSA-442749] CaMKK autophosphorylates in the nucleus - Homo sapiens [Reaction:R-HSA-9619127] CAMK4 binds KPNA2 - Homo sapiens [BlackBoxEvent:R-HSA-112282] CAMK4 enters the nucleus - Homo sapiens [Reaction:R-HSA-111913] Calmodulin binds CAMK4 - Homo sapiens [Reaction:R-HSA-9619125] CaMKK phosphorylates CAMK4 - Homo sapiens [Reaction:R-HSA-111915] CAMK4 autophosphorylates - Homo sapiens [Reaction:R-HSA-111912] CaMK4 phosphorylates CREB1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-12-13
literatureReference	[LiteratureReference:444790] Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus [LiteratureReference:9618774] Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory [LiteratureReference:9618772] ?CaMKII shuttles Ca�?/CaM to the nucleus to trigger CREB phosphorylation and gene expression
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
orthologousEvent	[Pathway:R-CEL-442729] CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde - Caenorhabditis elegans [Pathway:R-DME-442729] CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde - Drosophila melanogaster [Pathway:R-BTA-442729] CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde - Bos taurus [Pathway:R-CFA-442729] CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde - Canis familiaris [Pathway:R-RNO-442729] CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde - Rattus norvegicus [Pathway:R-MMU-442729] CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde - Mus musculus
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446792] Tukey, D, 2009-11-17 [InstanceEdit:9627687] Yi, Feng, 2018-11-02 [InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
revised	[InstanceEdit:9624342] Orlic-Milacic, Marija, 2018-10-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-442729
summation	[Summation:9620251] In addition to inducing long-term potentiation (LTP), NMDA r...
updateTrackers	[UpdateTracker:9778844] Update Tracker - [Pathway:442729] CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde - v67:[addLiteratureReference, add_removeHasEvent, add_removeSummation, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9778844] Update Tracker - [Pathway:442729] CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde - v67:[addLiteratureReference, add_removeHasEvent, add_removeSummation, updateContainedRLE]
(replacementInstances)	[Deleted:9628529] Deletion of instance: 442717 [Deleted:9628808] Deletion of instance: 442745
(hasEvent)	[Pathway:R-HSA-438064] Post NMDA receptor activation events

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