In addition to inducing long-term potentiation (LTP), NMDA receptor-mediated activation of CaMKII leads to transcriptional changes that are implicated in LTP maintenance (reviewed by Miyamoto 2006). CaMKII-gamma (CAMK2G) isoform is involved in nuclear shuttling of the calcium/calmodulin complex (CALM1:4xCa2+), which enables CaMKK-mediated activation of the nuclear calcium/calmodulin dependent kinase CaMKIV (CAMK4). Activated CaMKIV phosphorylates the transcription factor CREB1 and activates CREB1-mediated transcription (Ma et al. 2014, Cohen et al. 2018).
Tsien, RW, Emery, JF, Cohen, SM, Li, B, Zhang, G, Groth, RD, Neubert, TA, Hoedt, E, Ma, H
Salah, A, Sanchez, S, Tsien, RW, Zhou, G, Cohen, SM, Mandelberg, NJ, Suutari, B, Tirko, NN, Mullins, C, Wang, Y, Ma, H, He, X, Kats, I, Wang, S
Miyamoto, E
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