CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde

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Homo sapiens
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In addition to inducing long-term potentiation (LTP), NMDA receptor-mediated activation of CaMKII leads to transcriptional changes that are implicated in LTP maintenance (reviewed by Miyamoto 2006). CaMKII-gamma (CAMK2G) isoform is involved in nuclear shuttling of the calcium/calmodulin complex (CALM1:4xCa2+), which enables CaMKK-mediated activation of the nuclear calcium/calmodulin dependent kinase CaMKIV (CAMK4). Activated CaMKIV phosphorylates the transcription factor CREB1 and activates CREB1-mediated transcription (Ma et al. 2014, Cohen et al. 2018).

Literature References
PubMed ID Title Journal Year
29934532 Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory

Cohen, SM, Suutari, B, He, X, Wang, Y, Sanchez, S, Tirko, NN, Mandelberg, NJ, Mullins, C, Zhou, G, Wang, S, Kats, I, Salah, A, Tsien, RW, Ma, H

Nat Commun 2018
25303525 γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression

Ma, H, Groth, RD, Cohen, SM, Emery, JF, Li, B, Hoedt, E, Zhang, G, Neubert, TA, Tsien, RW

Cell 2014
16799259 Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus

Miyamoto, E

J Pharmacol Sci 2006
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