Reactome | SRC-1 phosphorylates SHB

Schema > Reaction > Entries

SRC-1 phosphorylates SHB Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity	[CatalystActivity:210268] protein tyrosine kinase activity of SRC-1 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
dbId	4420128
displayName	SRC-1 phosphorylates SHB
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-4420083] PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-4420196] VEGFA dimer:p-6Y-VEGFR2 dimer:SHB [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4420185] The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells [LiteratureReference:4420114] The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SRC-1 phosphorylates SHB
orthologousEvent	[Reaction:R-GGA-4420128] SRC-1 phosphorylates SHB - Gallus gallus [Reaction:R-XTR-4420128] SRC-1 phosphorylates SHB - Xenopus tropicalis [Reaction:R-SSC-4420128] SRC-1 phosphorylates SHB - Sus scrofa [Reaction:R-BTA-4420128] SRC-1 phosphorylates SHB - Bos taurus [Reaction:R-CFA-4420128] SRC-1 phosphorylates SHB - Canis familiaris [Reaction:R-RNO-4420128] SRC-1 phosphorylates SHB - Rattus norvegicus [Reaction:R-MMU-4420128] SRC-1 phosphorylates SHB - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-4420164] VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane]
precedingEvent	[Reaction:R-HSA-4420099] p-6Y-VEGFR2 binds SHB - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4420128
summation	[Summation:4420089] Association of SHB with VEGFR2 leads to its Src-dependent ty...

Referrals

(hasEvent)	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-HSA-4420083] PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2