Reactome | SRC-1 phosphorylates SHB

SRC-1 phosphorylates SHB

Stable Identifier

R-HSA-4420128

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Association of SHB with VEGFR2 leads to its Src-dependent tyrosine phosphorylation and activation (Holmqvist et al. 2003, Holmqvist et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
12464388	The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells Welsh, M, Holmqvist, K, Cross, M, Riley, D	Cell. Signal.	2003
15026417	The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration Rolny, C, Welsh, M, Rahimi, N, Cross, MJ, Holmqvist, K, Matsumoto, T, Claesson-Welsh, L, Hägerkvist, R	J. Biol. Chem.	2004