SRC-1 phosphorylates SHB

Stable Identifier
R-HSA-4420128
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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SRC-1 phosphorylates SHB
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Association of SHB with VEGFR2 leads to its Src-dependent tyrosine phosphorylation and activation (Holmqvist et al. 2003, Holmqvist et al. 2004).
Literature References
PubMed ID Title Journal Year
12464388 The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells

Holmqvist, K, Cross, M, Riley, D, Welsh, M

Cell. Signal. 2003
15026417 The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration

Holmqvist, K, Cross, MJ, Rolny, C, Hägerkvist, R, Rahimi, N, Matsumoto, T, Claesson-Welsh, L, Welsh, M

J. Biol. Chem. 2004
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of SRC-1 [cytosol]

Physical Entity
SRC-1 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
SRC-1 phosphorylates SHB (Bos taurus)
SRC-1 phosphorylates SHB (Canis familiaris)
SRC-1 phosphorylates SHB (Gallus gallus)
SRC-1 phosphorylates SHB (Mus musculus)
SRC-1 phosphorylates SHB (Rattus norvegicus)
SRC-1 phosphorylates SHB (Sus scrofa)
SRC-1 phosphorylates SHB (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Ballmer-Hofer, K  (2014-05-12)
Created
Garapati, P V  (2013-08-30)
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