SRC-1 phosphorylates SHB

Stable Identifier
R-HSA-4420128
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Association of SHB with VEGFR2 leads to its Src-dependent tyrosine phosphorylation and activation (Holmqvist et al. 2003, Holmqvist et al. 2004).

Literature References
PubMed ID Title Journal Year
15026417 The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration

Holmqvist, K, Cross, MJ, Rolny, C, Hägerkvist, R, Rahimi, N, Matsumoto, T, Claesson-Welsh, L, Welsh, M

J. Biol. Chem. 2004
12464388 The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells

Holmqvist, K, Cross, M, Riley, D, Welsh, M

Cell. Signal. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of SRC-1 [cytosol]
Physical Entity
Activity
Orthologous Events
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Created