SRC-1 phosphorylates SHB

Stable Identifier
R-HSA-4420128
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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SRC-1 phosphorylates SHB
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Association of SHB with VEGFR2 leads to its Src-dependent tyrosine phosphorylation and activation (Holmqvist et al. 2003, Holmqvist et al. 2004).

Literature References
PubMed ID Title Journal Year
12464388 The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells

Welsh, M, Holmqvist, K, Cross, M, Riley, D

Cell. Signal. 2003
15026417 The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration

Rolny, C, Welsh, M, Rahimi, N, Cross, MJ, Holmqvist, K, Matsumoto, T, Claesson-Welsh, L, Hägerkvist, R

J. Biol. Chem. 2004
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of SRC-1 [cytosol]

Physical Entity
SRC-1 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
SRC-1 phosphorylates SHB (Canis familiaris)
SRC-1 phosphorylates SHB (Gallus gallus)
SRC-1 phosphorylates SHB (Mus musculus)
SRC-1 phosphorylates SHB (Rattus norvegicus)
SRC-1 phosphorylates SHB (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2013-08-30)
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