SRC-1 phosphorylates SHB

Stable Identifier
R-HSA-4420128
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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SRC-1 phosphorylates SHB
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Association of SHB with VEGFR2 leads to its Src-dependent tyrosine phosphorylation and activation (Holmqvist et al. 2003, Holmqvist et al. 2004).

Literature References
PubMed ID Title Journal Year
15026417 The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration

Holmqvist, K, Cross, MJ, Rolny, C, Hägerkvist, R, Rahimi, N, Matsumoto, T, Claesson-Welsh, L, Welsh, M

J. Biol. Chem. 2004
12464388 The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells

Holmqvist, K, Cross, M, Riley, D, Welsh, M

Cell. Signal. 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of SRC-1 [cytosol]
Physical Entity
SRC-1 [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
SRC-1 phosphorylates SHB (Canis familiaris)
SRC-1 phosphorylates SHB (Gallus gallus)
SRC-1 phosphorylates SHB (Mus musculus)
SRC-1 phosphorylates SHB (Rattus norvegicus)
SRC-1 phosphorylates SHB (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Ballmer-Hofer, K  (2014-05-12)
Created
Garapati, P V  (2013-08-30)
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