Reactome | PECAM1 is phosphorylated

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PECAM1 is phosphorylated Show undefined attributes

authored	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:435242] Jupe, S, 2009-09-08
dbId	435244
displayName	PECAM1 is phosphorylated
edited	[InstanceEdit:870306] Jupe, S, 2010-06-07
eventOf	[Pathway:R-HSA-432142] Platelet sensitization by LDL - Homo sapiens
followingEvent	[Reaction:R-HSA-432143] PECAM-1 binds PP2A - Homo sapiens [Reaction:R-HSA-210277] Interaction of PECAM-1 and SHP-1 - Homo sapiens [Reaction:R-HSA-210294] Interaction of PECAM-1 and SHP-2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-114686] PECAM1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:432091] Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits low density lipoprotein-induced signaling in platelets
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PECAM1 is phosphorylated
orthologousEvent	[BlackBoxEvent:R-GGA-435244] PECAM1 is phosphorylated - Gallus gallus [BlackBoxEvent:R-DRE-435244] PECAM1 is phosphorylated - Danio rerio [BlackBoxEvent:R-SSC-435244] PECAM1 is phosphorylated - Sus scrofa [BlackBoxEvent:R-BTA-435244] PECAM1 is phosphorylated - Bos taurus [BlackBoxEvent:R-CFA-435244] PECAM1 is phosphorylated - Canis familiaris [BlackBoxEvent:R-RNO-435244] PECAM1 is phosphorylated - Rattus norvegicus [BlackBoxEvent:R-MMU-435244] PECAM1 is phosphorylated - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-210007] p-Y663,Y686-PECAM1(27-?) [plasma membrane]
regulatedBy	[PositiveRegulation:R-HSA-9006351] Positive regulation by 'LDL [extracellular region]'
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-435244
summation	[Summation:435243] LDL causes a transient increase in p38 MAPK activity in plat...
updateTrackers	[UpdateTracker:9781190] Update Tracker - [BlackBoxEvent:435244] PECAM1 is phosphorylated - v61:[addOutput, addRegulator, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781190] Update Tracker - [BlackBoxEvent:435244] PECAM1 is phosphorylated - v61:[addOutput, addRegulator, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-432142] Platelet sensitization by LDL
(precedingEvent)	[Reaction:R-HSA-432143] PECAM-1 binds PP2A [Reaction:R-HSA-210277] Interaction of PECAM-1 and SHP-1 [Reaction:R-HSA-210294] Interaction of PECAM-1 and SHP-2