PECAM1 is phosphorylated

Stable Identifier
R-HSA-435244
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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LDL causes a transient increase in p38 MAPK activity in platelets. After an initial phase in which LDL leads to the activation of p38MAPK, LDL leads to tyrosine phosphorylation and thereby activation of PECAM-1, which in turn leads to binding and stimulation of the Ser/Thr phosphatases PP1/PP2A which reduce the activity of p38MAPK by dephosphorylation.

Literature References
PubMed ID Title Journal Year
12775720 Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits low density lipoprotein-induced signaling in platelets

Relou, IA, Gorter, G, Ferreira, IA, van Rijn, HJ, Akkerman, JW

J Biol Chem 2003
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This event is regulated
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