Autophosphorylation and activation of CAMK2

Stable Identifier
R-HSA-4332363
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Binding of CaM to CAMK2 displaces the autoinhibitory loop from the active site and allows CAMK2 to autophosphorylate T286, resulting in CAMK2 activation (reveiwed in Stratton et al, 2013).

Literature References
PubMed ID Title Journal Year
23632248 Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II

Stratton, MM, Chao, LH, Schulman, H, Kuriyan, J

Curr. Opin. Struct. Biol. 2013
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of CAMK2:CaM [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created