Reactome | Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)

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Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) Show undefined attributes

authored	[InstanceEdit:432201] May, B, 2009-08-11
catalystActivity	[CatalystActivity:163671] cAMP-dependent protein kinase activity of PKA catalytic subunit [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13946] transport vesicle membrane
created	[InstanceEdit:432236] May, B, 2009-08-12
dbId	432232
displayName	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
edited	[InstanceEdit:432201] May, B, 2009-08-11
eventOf	[Pathway:R-HSA-432040] Vasopressin regulates renal water homeostasis via Aquaporins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-432237] Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane - Homo sapiens
input	[Complex:R-HSA-432228] AQP2 tetramer [transport vesicle membrane] 4 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:432214] The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel [LiteratureReference:432240] Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
orthologousEvent	[Reaction:R-PFA-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Plasmodium falciparum [Reaction:R-DDI-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Dictyostelium discoideum [Reaction:R-DME-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Drosophila melanogaster [Reaction:R-GGA-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Gallus gallus [Reaction:R-XTR-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Xenopus tropicalis [Reaction:R-DRE-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Danio rerio [Reaction:R-SSC-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Sus scrofa [Reaction:R-BTA-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Bos taurus [Reaction:R-RNO-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Rattus norvegicus [Reaction:R-MMU-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-432217] p-S256-AQP2 tetramer [transport vesicle membrane]
precedingEvent	[Reaction:R-HSA-111925] cAMP induces dissociation of inactive PKA tetramers - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:879857] Beitz, E, 2010-06-24 [InstanceEdit:913479] Calamita, G, 2010-07-15 [InstanceEdit:918100] Mathai, JC, MacIver, B, 2010-07-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-432232
summation	[Summation:432239] Activated Protein Kinase A phosphorylates Aquaporin-2 at Ser...
updateTrackers	[UpdateTracker:9779038] Update Tracker - [Reaction:432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - v66:[addInput, addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9779038] Update Tracker - [Reaction:432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - v66:[addInput, addOutput]
(hasEvent)	[Pathway:R-HSA-432040] Vasopressin regulates renal water homeostasis via Aquaporins
(precedingEvent)	[BlackBoxEvent:R-HSA-432237] Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane

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