Reactome | Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)

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Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) Show undefined attributes

catalystActivity	[CatalystActivity:11011381] cAMP-dependent protein kinase activity of PKA catalytic subunit [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13946] transport vesicle membrane
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11011383
displayName	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
eventOf	[Pathway:R-DDI-432040] Vasopressin regulates renal water homeostasis via Aquaporins - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Homo sapiens
input	[Complex:R-DDI-432228] AQP2 tetramer [transport vesicle membrane] 4 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DDI-432217] p-S256-AQP2 tetramer [transport vesicle membrane]
precedingEvent	[Reaction:R-DDI-111925] cAMP induces dissociation of inactive PKA tetramers - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-432232
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-432040] Vasopressin regulates renal water homeostasis via Aquaporins
(inferredTo)	[Reaction:R-HSA-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)

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