Reactome | Aquaporin-4 passively transports water out of cell

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Aquaporin-4 passively transports water out of cell Show undefined attributes

authored	[InstanceEdit:432015] May, B, 2009-08-06
catalystActivity	[CatalystActivity:432066] water channel activity of AQP4 tetramer [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643677] water channel activity of AQP4 tetramer [plasma membrane] Novel variants in human Aquaporin-4 reduce cellular water permeability
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:432025] May, B, 2009-08-08
crossReference	[DatabaseIdentifier:12668144] RHEA:29667
dbId	432067
displayName	Aquaporin-4 passively transports water out of cell
edited	[InstanceEdit:432015] May, B, 2009-08-06
eventOf	[Pathway:R-HSA-432040] Vasopressin regulates renal water homeostasis via Aquaporins - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:431887] Distribution of the AQP4 water channel in normal human tissues: protein and tissue microarrays reveal expression in several new anatomical locations, including the prostate gland and seminal vesicles [LiteratureReference:431970] Novel variants in human Aquaporin-4 reduce cellular water permeability [LiteratureReference:503934] Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance [LiteratureReference:504003] Identification of arylsulfonamides as Aquaporin 4 inhibitors [LiteratureReference:503973] Aquaporin expression in normal human kidney and in renal disease [LiteratureReference:503990] The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Aquaporin-4 passively transports water out of cell
orthologousEvent	[Reaction:R-PFA-432067] Aquaporin-4 passively transports water out of cell - Plasmodium falciparum [Reaction:R-DDI-432067] Aquaporin-4 passively transports water out of cell - Dictyostelium discoideum [Reaction:R-DME-432067] Aquaporin-4 passively transports water out of cell - Drosophila melanogaster [Reaction:R-GGA-432067] Aquaporin-4 passively transports water out of cell - Gallus gallus [Reaction:R-XTR-432067] Aquaporin-4 passively transports water out of cell - Xenopus tropicalis [Reaction:R-DRE-432067] Aquaporin-4 passively transports water out of cell - Danio rerio [Reaction:R-SSC-432067] Aquaporin-4 passively transports water out of cell - Sus scrofa [Reaction:R-BTA-432067] Aquaporin-4 passively transports water out of cell - Bos taurus [Reaction:R-CFA-432067] Aquaporin-4 passively transports water out of cell - Canis familiaris [Reaction:R-RNO-432067] Aquaporin-4 passively transports water out of cell - Rattus norvegicus [Reaction:R-MMU-432067] Aquaporin-4 passively transports water out of cell - Mus musculus
output	[SimpleEntity:R-ALL-109276] H2O [extracellular region]
precedingEvent	[Reaction:R-HSA-432065] p-S256-Aquaporin-2 passively transports water into cell - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:879857] Beitz, E, 2010-06-24 [InstanceEdit:913479] Calamita, G, 2010-07-15 [InstanceEdit:918100] Mathai, JC, MacIver, B, 2010-07-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-432067
summation	[Summation:431732] Aquaporin-4 (AQP4) passively transports water across the pla...

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(hasEvent)

[Pathway:R-HSA-432040] Vasopressin regulates renal water homeostasis via Aquaporins

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