Aquaporin-4 passively transports water out of cell

Stable Identifier
R-HSA-432067
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aquaporin-4 (AQP4) passively transports water across the plasma membrane according to the osmotic gradient. AQP4 is expressed in the collecting duct of the kidney and in astroglial cells at the blood-brain barrier and ependymal cells lining the ventricles of the brain.

Literature References
PubMed ID Title Journal Year
19170255 Distribution of the AQP4 water channel in normal human tissues: protein and tissue microarrays reveal expression in several new anatomical locations, including the prostate gland and seminal vesicles

Mobasheri, A, Marples, D, Young, IS, Floyd, RV, Moskaluk, CA, Frigeri, A

Channels (Austin) 2007
19383790 Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

Ho, JD, Yeh, R, Sandstrom, A, Chorny, I, Harries, WE, Robbins, RA, Miercke, LJ, Stroud, RM

Proc Natl Acad Sci U S A 2009
17178220 Identification of arylsulfonamides as Aquaporin 4 inhibitors

Huber, VJ, Tsujita, M, Yamazaki, M, Sakimura, K, Nakada, T

Bioorg Med Chem Lett 2007
18511455 Novel variants in human Aquaporin-4 reduce cellular water permeability

Sorani, MD, Zador, Z, Hurowitz, E, Yan, D, Giacomini, KM, Manley, GT

Hum Mol Genet 2008
14514735 Aquaporin expression in normal human kidney and in renal disease

Bedford, JJ, Leader, JP, Walker, RJ

J Am Soc Nephrol 2003
8855281 The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain

Lu, M, Lee, MD, Smith, BL, Jung, JS, Agre, P, Verdijk, MA, Merkx, G, Rijss, JP, Deen, PM

Proc Natl Acad Sci U S A 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
water channel activity of AQP4 tetramer [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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