Reactome | Aquaporin-4 passively transports water out of cell

Aquaporin-4 passively transports water out of cell

Stable Identifier

R-HSA-432067

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Aquaporin-4 passively transports water out of cell

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Aquaporin-4 (AQP4) passively transports water across the plasma membrane according to the osmotic gradient. AQP4 is expressed in the collecting duct of the kidney and in astroglial cells at the blood-brain barrier and ependymal cells lining the ventricles of the brain.

Literature References

PubMed ID	Title	Journal	Year
19383790	Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance Ho, JD, Yeh, R, Sandstrom, A, Chorny, I, Harries, WE, Robbins, RA, Miercke, LJ, Stroud, RM	Proc Natl Acad Sci U S A	2009
19170255	Distribution of the AQP4 water channel in normal human tissues: protein and tissue microarrays reveal expression in several new anatomical locations, including the prostate gland and seminal vesicles Mobasheri, A, Marples, D, Young, IS, Floyd, RV, Moskaluk, CA, Frigeri, A	Channels (Austin)	2007
17178220	Identification of arylsulfonamides as Aquaporin 4 inhibitors Huber, VJ, Tsujita, M, Yamazaki, M, Sakimura, K, Nakada, T	Bioorg Med Chem Lett	2007
18511455	Novel variants in human Aquaporin-4 reduce cellular water permeability Sorani, MD, Zador, Z, Hurowitz, E, Yan, D, Giacomini, KM, Manley, GT	Hum Mol Genet	2008
14514735	Aquaporin expression in normal human kidney and in renal disease Bedford, JJ, Leader, JP, Walker, RJ	J Am Soc Nephrol	2003
8855281	The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain Lu, M, Lee, MD, Smith, BL, Jung, JS, Agre, P, Verdijk, MA, Merkx, G, Rijss, JP, Deen, PM	Proc Natl Acad Sci U S A	1996