Reactome | Aquaporin-4 passively transports water out of cell

Schema > Reaction > Entries

Aquaporin-4 passively transports water out of cell Show undefined attributes

catalystActivity	[CatalystActivity:10256572] water channel activity of AQP4 tetramer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10256574
displayName	Aquaporin-4 passively transports water out of cell
eventOf	[Pathway:R-CFA-432040] Vasopressin regulates renal water homeostasis via Aquaporins - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-432067] Aquaporin-4 passively transports water out of cell - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Aquaporin-4 passively transports water out of cell
output	[SimpleEntity:R-ALL-109276] H2O [extracellular region]
precedingEvent	[Reaction:R-CFA-432065] p-S256-Aquaporin-2 passively transports water into cell - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-432067
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-432040] Vasopressin regulates renal water homeostasis via Aquaporins
(inferredTo)	[Reaction:R-HSA-432067] Aquaporin-4 passively transports water out of cell

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