Reactome | Dissociation of the TP:Gq complex

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Dissociation of the TP:Gq complex Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:428751] Jupe, S, 2009-07-09
dbId	428752
displayName	Dissociation of the TP:Gq complex
edited	[InstanceEdit:445674] Jupe, S, 2009-11-03
eventOf	[Pathway:R-HSA-428930] Thromboxane signalling through TP receptor - Homo sapiens
followingEvent	[Reaction:R-HSA-416510] GRK5 sequesters activated Gq - Homo sapiens [Reaction:R-HSA-418582] G alpha (q) auto-inactivates by hydrolysing GTP to GDP - Homo sapiens [Reaction:R-HSA-400586] G alpha (q) binds to Trio family RhoGEFs - Homo sapiens [Reaction:R-HSA-398188] PLC beta is activated by G alpha (q) - Homo sapiens [Reaction:R-HSA-416516] GRK2 sequesters activated Gq - Homo sapiens [Reaction:R-HSA-416358] G alpha (q) inhibits PI3K alpha - Homo sapiens
input	[Complex:R-HSA-428904] TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Dissociation of the TP:Gq complex
orthologousEvent	[Reaction:R-GGA-428752] Dissociation of the TP:Gq complex - Gallus gallus [Reaction:R-BTA-428752] Dissociation of the TP:Gq complex - Bos taurus [Reaction:R-CFA-428752] Dissociation of the TP:Gq complex - Canis familiaris [Reaction:R-MMU-428752] Dissociation of the TP:Gq complex - Mus musculus
output	[Complex:R-HSA-114534] G-protein alpha (q/11): GTP [plasma membrane] [Complex:R-HSA-167434] G-protein beta-gamma complex [plasma membrane] [EntityWithAccessionedSequence:R-HSA-391837] TBXA2R [plasma membrane] [SimpleEntity:R-ALL-391932] TXA2 [extracellular region]
precedingEvent	[Reaction:R-HSA-428750] Gq activation by TP receptor - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:445668] Poole, AW, 2009-11-02 [InstanceEdit:445653] Jones, ML, 2009-11-02 [InstanceEdit:445649] Harper, MT, 2009-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-428752
summation	[Summation:392198] The classical view of G-protein signalling is that the G-pro...
updateTrackers	[UpdateTracker:9790505] Update Tracker - [Reaction:428752] Dissociation of the TP:Gq complex - v33:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790505] Update Tracker - [Reaction:428752] Dissociation of the TP:Gq complex - v33:[modifyText]
(hasEvent)	[Pathway:R-HSA-428930] Thromboxane signalling through TP receptor
(precedingEvent)	[Reaction:R-HSA-416510] GRK5 sequesters activated Gq [Reaction:R-HSA-418582] G alpha (q) auto-inactivates by hydrolysing GTP to GDP [Reaction:R-HSA-400586] G alpha (q) binds to Trio family RhoGEFs [Reaction:R-HSA-398188] PLC beta is activated by G alpha (q) [Reaction:R-HSA-416516] GRK2 sequesters activated Gq [Reaction:R-HSA-416358] G alpha (q) inhibits PI3K alpha