Reactome | 2-AG hydrolysis to arachidonate by MAGL

Schema > Reaction > Entries

2-AG hydrolysis to arachidonate by MAGL Show undefined attributes

authored	[InstanceEdit:426042] Jupe, S, 2009-06-11
catalystActivity	[CatalystActivity:426275] monoacylglycerol lipase activity of MGLL [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:426042] Jupe, S, 2009-06-11
crossReference	[DatabaseIdentifier:12667889] RHEA:26132
dbId	426043
displayName	2-AG hydrolysis to arachidonate by MAGL
edited	[InstanceEdit:435382] Jupe, S, 2009-09-09
eventOf	[Pathway:R-HSA-426048] Arachidonate production from DAG - Homo sapiens
input	[SimpleEntity:R-ALL-426030] 2AG [plasma membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:426051] Release of arachidonate from diglyceride in human platelets requires the sequential action of a diglyceride lipase and a monoglyceride lipase [LiteratureReference:426418] A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	2-AG hydrolysis to arachidonate by MAGL
orthologousEvent	[Reaction:R-SCE-426043] 2-AG hydrolysis to arachidonate by MAGL - Saccharomyces cerevisiae [Reaction:R-SPO-426043] 2-AG hydrolysis to arachidonate by MAGL - Schizosaccharomyces pombe [Reaction:R-DDI-426043] 2-AG hydrolysis to arachidonate by MAGL - Dictyostelium discoideum [Reaction:R-GGA-426043] 2-AG hydrolysis to arachidonate by MAGL - Gallus gallus [Reaction:R-XTR-426043] 2-AG hydrolysis to arachidonate by MAGL - Xenopus tropicalis [Reaction:R-DRE-426043] 2-AG hydrolysis to arachidonate by MAGL - Danio rerio [Reaction:R-SSC-426043] 2-AG hydrolysis to arachidonate by MAGL - Sus scrofa [Reaction:R-BTA-426043] 2-AG hydrolysis to arachidonate by MAGL - Bos taurus [Reaction:R-CFA-426043] 2-AG hydrolysis to arachidonate by MAGL - Canis familiaris [Reaction:R-RNO-426043] 2-AG hydrolysis to arachidonate by MAGL - Rattus norvegicus [Reaction:R-MMU-426043] 2-AG hydrolysis to arachidonate by MAGL - Mus musculus
output	[SimpleEntity:R-ALL-422506] AA [plasma membrane] [SimpleEntity:R-ALL-76116] Glycerol [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-426032] DAG is metabolized by DAGL to 2-AG - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-426043
summation	[Summation:426423] Monoacylglycerol lipase (MAGL) is a key enzyme in the hydrol...
updateTrackers	[UpdateTracker:9790088] Update Tracker - [Reaction:426043] 2-AG hydrolysis to arachidonate by MAGL - v35:[addInput, addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9790088] Update Tracker - [Reaction:426043] 2-AG hydrolysis to arachidonate by MAGL - v35:[addInput, addOutput]
(hasEvent)	[Pathway:R-HSA-426048] Arachidonate production from DAG