2-AG hydrolysis to arachidonate by MAGL

Stable Identifier
R-HSA-426043
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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Monoacylglycerol lipase (MAGL) is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol to arachidonate and glycerol. In adipocytes MAGL and hormone-sensitive lipase (LIPE) hydrolyze intracellular triglyceride stores. MAGL may also complement lipoprotein lipase (LPL) in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.
Literature References
Participants
Participates
Catalyst Activity

acylglycerol lipase activity of MGLL [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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