2-AG hydrolysis to arachidonate by MAGL

Stable Identifier
R-HSA-426043
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Monoacylglycerol lipase (MAGL) is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol to arachidonate and glycerol. In adipocytes MAGL and hormone-sensitive lipase (LIPE) hydrolyze intracellular triglyceride stores. MAGL may also complement lipoprotein lipase (LPL) in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acylglycerol lipase activity of MGLL [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created
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