Reactome | IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced

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IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced Show undefined attributes

authored	[InstanceEdit:425354] May, B, 2009-06-03
catalystActivity	[CatalystActivity:381180] RNA endonuclease activity of p-S724-IRE1 dimer:ADP [endoplasmic reticulum membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:425922] May, B, 2009-06-08
dbId	425923
displayName	IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced
edited	[InstanceEdit:425354] May, B, 2009-06-03
eventOf	[Pathway:R-HSA-381070] IRE1alpha activates chaperones - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-381203] XBP(S) mRNA is translated and XBP1(S) translocates to the nucleus - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-425921] Xbp1 mRNA (unspliced) [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:381050] XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor [LiteratureReference:535546] Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response [LiteratureReference:535581] RNase domains determine the functional difference between IRE1alpha and IRE1beta [LiteratureReference:535478] Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced
output	[EntityWithAccessionedSequence:R-HSA-425925] Xbp1 mRNA (spliced) [cytosol]
precedingEvent	[Reaction:R-HSA-381116] Phosphorylated IRE1 dimer binds ADP - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 [InstanceEdit:638652] Urano, F, 2010-04-30
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-425923
summation	[Summation:425924] Phosphorylated IRE1-alpha homodimers with bound ADP have end...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-381203] XBP(S) mRNA is translated and XBP1(S) translocates to the nucleus
(hasEvent)	[Pathway:R-HSA-381070] IRE1alpha activates chaperones

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